Psychiatrists could prescribe metformin for weight gain

Metformin has been associated with clinically significant weight loss in people taking the anti-psychotic clozapine. The systematic review and meta-analysis that included eight studies of people taking clozapine who did not have diabetes found that metformin was superior to placebo in terms of weight loss (-3.12kg, 95%CI -4.88kg to -1.37kg) and BMI (-1.18kg/m2, 95%CI -1.76kg/m2 ...

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