Levothyroxine of no benefit in SCH with high symptom burden

Patients with subclinical hypothyroidism do not benefit from levothyroxine regardless of their level of symptoms, a major European trial shows. Older patients with a high symptom burden showed no apparent improvement with levothyroxine compared to placebo according to a posthoc analysis of the randomised, placebo-controlled trial TRUST (Thyroid Hormone Replacement for Untreated Older Adults with ...

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