endocrinology
Bone health

Known risk of hypocalcemia with denosumab may have been underestimated

Denosumab-induced hypocalcemia may be more common than expected in osteoporotic men and women, according to real world data. An Israeli study of more than 2,000 community-living adults with osteoporosis treated with 60 mg denosumab every six months found 7.4% developed hypocalcemia (<8.5mg/dL). This rate is significantly higher than that seen in clinical trials (0.05-1.7 mg/dL). ...

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