A systematic review of the evidence has determined that high dose oral ibuprofen is the best pharmacotherapeutic option for closure of a haemodynamically significant patent ductus arteriosus (PDA). The review comprised 68 randomised clinical trials and almost 5,000 pre-term infants receiving indomethacin, ibuprofen or acetaminophen according to about 14 different doses, routes and methods of ...
Jury out on medical management of patent ductus arteriosus
By Mardi Chapman
29 Mar 2018