Jury out on medical management of patent ductus arteriosus

A systematic review of the evidence has determined that high dose oral ibuprofen is the best pharmacotherapeutic option for closure of a haemodynamically significant patent ductus arteriosus (PDA). The review comprised 68 randomised clinical trials and almost 5,000 pre-term infants receiving indomethacin, ibuprofen or acetaminophen according to about 14 different doses, routes and methods of ...

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